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This course deals with the structure, function and chemistry of the molecular building blocks of the cell. This includes a discussion of water and its properties, amino acids, proteins, nucleotides and nucleic acids, carbohydrates and lipids. Also included is an introduction to enzyme function and kinetics. The laboratory provides an introduction to the basic biochemical techniques including chromatography, electrophoresis and spectrophotometry. (Formerly CHY 261).
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Lect: 3 hrs./Lab: 3 hrs.
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| Prerequisite: BLG 143 and BLG 144 and CHY 142
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GPA Weight: 1.00
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Billing Units: 1
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BCH
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361
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Advanced Biochemistry I
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A course in the principles of enzymology, bioenergetics and carbohydrate metabolism. Enzymology topics include the structure, function and regulation of enzymes and Michaelis-Menten kinetics. The fundamentals of bioenergetics and intermediary metabolism are discussed in the context of the integration and control of catabolism and anabolism. The course concludes with a detailed examination of carbohydrate chemistry with emphasis on the chemical logic and the regulation of these pathways. The laboratory introduces students to more advanced biochemical techniques. Topics include the isolation and characterization of polysaccharides and the kinetic analysis of enzymes. (Formerly CHY 361).
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Lect: 3 hrs./Lab: 3 hrs.
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| Prerequisite: CHY 261 or BCH 261
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GPA Weight: 1.00
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Billing Units: 1
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BCH
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461
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Biochemistry of Disease
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This course will examine the etiology and pathogenesis of biochemical disorders of diseases. The course will include applications of biochemistry, chemistry and immunology as they relate to the diagnosis, therapy, and monitoring of human disease.
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Lect: 3 hrs.
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| Prerequisites: BLG 400, BCH 361
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GPA Weight: 1.00
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Billing Units: 1
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BCH
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463
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Advanced Biochemistry II
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The major topics examined are membrane structure and transport systems and cellular metabolic pathways. A review of DNA replication and protein synthesis will also be included. A detailed examination of the metabolism of lipids, proteins and nucleic acids is investigated in the context of normal function in various organisms. The contribution of disrupted metabolism to human diseases such as cancer and diabetes is also discussed.
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Lect: 3 hrs.
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| Prerequisite: BCH 361 or CHY 361; Antirequisite: BCH 362 and CHY 362
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GPA Weight: 1.00
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Billing Units: 1
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BCH
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501
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Protein Biochem and Proteomics
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In depth examination of protein structure and function, tools for determining biochemical function and structure, analysis of protein-protein interactions, regulatory mechanisms, introduction to high throughput identification and quantification of protein expression; application of proteomics to drug design.
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Lect: 3 hrs.
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| Prerequisites: BCH 261 and BCH 361
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GPA Weight: 1.00
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Billing Units: 1
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This course deals with the role of carbohydrates and their conjugates in biology and disease. Topics will include the monosaccharide building blocks and their linkages, glycoconjugates (glycoproteins, glycolipids and proteoglycans), their physiological functions and how they are synthesized. The roles of carbohydrate receptors in molecular recognition, the roles of lectins and other specialized carbohydrate binding proteins: glycobiology of microbes, viruses and plants; glycobiology and disease; glycans as renewable bio-energy sources.
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Lect: 3 hrs.
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| Prerequisites: BLG 311 and BCH 361
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GPA Weight: 1.00
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Billing Units: 1
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BCH
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560
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Protein Structure and Function
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This course will provide a set of key concepts that govern a true understanding and appreciation of why proteins are the workhorses of the cell. Students will be exposed to these concepts in both traditional lecture and presentation environments. Some of the key concepts will include: 1) understanding basic protein structure elements and how they play a role in function, 2) methods for protein structure determination and visualization including an introduction to the use of Pymol, 3) enzyme mediated chemical reactions, and 4) binding proteins and their role in signaling.
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Lect: 3 hrs.
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| Prerequisite: BCH 261
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GPA Weight: 1.00
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Billing Units: 1
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The course examines mechanisms of signal transduction and intracellular signalling. We will first examine the biochemical tools of signalling pathways including receptor families and their ligands, second messengers, G-Proteins and protein phosphorylation switches. We will then investigate the signalling pathways and networks in biological functions, which may include stress-response, blood pressure control, cell growth, cell migration, and the immune response.
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Lect: 3 hrs.
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| Prerequisite: BLG 311 and BLG 411 and (CHY 261 or BCH 261)
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GPA Weight: 1.00
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Billing Units: 1
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BCH
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880
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Advanced Biochemistry Laboratory
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This course will cover experiments on the study and characterization of proteins, with a particular focus on membrane proteins. The lab experience includes experiments for protein solubility, electrophoresis, as well as detection of proteins by glycoprotein staining and western blotting. Other protein detection methods examined in this course will include enzyme-linked immunoassays (ELISA). Students will also give presentations on emerging methodologies.
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Lab: 3 hrs.
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| Corequisite: :BCH 361 or CHY 361; Antirequisite: BLG 888
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GPA Weight: 1.00
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Billing Units: 1
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