Sensitive Detection and Accurate Quantification of Biomolecules
Research Critical to Improving Diagnostic & Therapeutic Methods for Medicine and Public Health
Welcome to our world of analytical biochemistry: we study extracellular or circulating proteins and peptides in the blood and their receptors on cell surfaces.
In the field of proteomics, the Marshall Team has implemented large-scale comparisons of blood proteins and peptides, or secreted proteins, between normal and disease using sophisticated database and statistical analysis.
ELiMSA® (Enzyme-Linked Mass Spectrometric Assay) was invented and patented as an ultra-sensitive detection method that has pushed the edges of detection, accuracy and quantification of biomolecules. ELiMSA® is the only existing linear and Gaussian detection method that reaches single molecule range (Yoctomole).
Our Goals
- Push the limits of sensitive quantification and accurate detection to improve on diagnostic and therapeutic methods important to medicine and public health
- Collaborate with academic and commercial partners within Canada and internationally
- Steward inquisitive researchers to work hard, think critically and advance science
“Detecting and quantifying biomolecules accurately and sensitively helps advance medical and public health diagnostics and therapies. Our research can detect a wide range of viruses and diseases, such as COVID-19, HIV, cancer, Alzheimer’s, as well as food and water pathogens. Our goal is to push the limits of accurate and sensitive testing.”
News & Events
- February 21, 2025YYZ Pharmatech Inc. announces residency at JLABS, TorontoOpens in New WindowThe Marshall Team partner YYZ Pharmatech Inc. joins community of innovators at prestigious incubator network JLABSNews Subtitle:
- February 2, 2021The Marshall Team recently published a ground-breaking paper in the Journal of the American Society for Mass SpectrometryOpens in New WindowLinear and Gaussian Analysis of a Single Enzyme Molecule by LC–MSNews Subtitle:
- January 12, 2021How a Ryerson-led team is developing an ultra-sensitive testing technology for COVID-19 and beyondProfessor John G. Marshall and YYZ Pharmatech Inc. have created a new detection methodNews Subtitle:
Past Conferences:
- Event Title:(2024). Federation of Analytical Chemistry and Spectroscopy Societies October 20-25, 2024, Raleigh, North Carolina, USA
- Event Title:(2024). Canadian Chemistry Conference and Exhibition (CSC 2024) June 2-6, 2024, Winnipeg, Manitoba
- Event Title:(2023). Mitochondria and cytochrome components released into the plasma of severe COVID#19 and ICU acute respiratory distress syndrome patients. Federation of Analytical Chemistry and Spectroscopy Societies October 8-13, 2023, Reno NV, United States of America
- Event Title:(2023). Analysis of COVID-19 plasma proteins samples by LC-ESI-MS/MS. Taiwan Society for Mass Spectrometry 20th Conference, Taichung, Taiwan
- Event Title:(2023). Direct ELIMSA assay of COVID spike protein and serological response. National Taiwan Normal University, Department of Chemistry, June 27th, Taipei, Taiwan
- Event Title:(2023). A novel nucleic acid detection technique for SARS-CoV-2: DNA enzyme linked mass spectrometric assay (DNA ELiMSA. Canadian Society of Chemistry CCCE, Vancouver, Canada)
- Event Title:(2023). Analysis of COVID, HIV and puC19 DNA by Enzyme Linked Mass Spectrometric Assay. National Taiwan Normal University (NTNU), Taipei, Taiwan
- Event Title:(2022). Ultrasensitive detection and quantification of HIV cDNA and its polymerase chain reaction products by a novel enzyme linked mass spectrometric assay. Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) Oct 4, Covington KY, United States of America
- Event Title:(2022). Mitochondrial proteins released into the plasma of Severe COVID-19 and ICU Acute Respiratory Distress Syndrome Patients. Canadian Society of Chemistry, Calgary, Canada
- Event Title:(2021). Linear and Gaussian analysis of a single enzyme molecule by LC-MS. Canadian Society of Chemistry CSC CCCE IUPAC, VIRTUAL COVID, Canada
- Event Title:(2021). Linear and Gaussian Analysis of a Single Enzyme Molecule by LC-MS. (2021) 18th ISEAC & 4rd ECL Electronic Changchun, Jilin, China, August 26 (IS), Changchun, Jilin, China, China
- Event Title:(2019). The proteins and peptide of fetal versus adult serum. 102 Canadian Society of Chemistry, Quebec, Canada
- Event Title:(2019). An ELIMSA assay of HIV. 17th ISEAC and 3rd ECL, Changchun, China
