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This course deals with the structure, function and chemistry of the molecular building blocks of the cell. This includes a discussion of water and its properties, amino acids, proteins, nucleotides and nucleic acids, carbohydrates and lipids. Also included is an introduction to enzyme function and kinetics. The laboratory provides an introduction to the basic biochemical techniques including chromatography, electrophoresis and spectrophotometry. (Formerly CHY 261).
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Lect: 3 hrs./Lab: 3 hrs.
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| Prerequisite: CHY 142
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Course Weight: 1.00
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Billing Units: 1
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BCH
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361
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Advanced Biochemistry I
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A course in the principles of enzymology, bioenergetics and carbohydrate metabolism. Enzymology topics include the structure, function and regulation of enzymes and Michaelis-Menten kinetics. The fundamentals of bioenergetics and intermediary metabolism are discussed in the context of the integration and control of catabolism and anabolism. The course concludes with a detailed examination of carbohydrate chemistry with emphasis on the chemical logic and the regulation of these pathways. The laboratory introduces students to more advanced biochemical techniques. Topics include the isolation and characterization of polysaccharides and the kinetic analysis of enzymes. (Formerly CHY 361).
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Lect: 3 hrs./Lab: 3 hrs.
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| Prerequisite: CHY 261 or BCH 261
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Course Weight: 1.00
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Billing Units: 1
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BCH
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362
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Advanced Biochemistry II
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The major topics introduced in the lectures are membrane structure and transport systems and the metabolism of lipids, proteins and nucleic acids. A review of DNA replication and protein synthesis will also be included. The laboratory focuses on chromatography and electrophoresis as used to separate and analyze proteins. Students are required to write a major report(s), make an oral presentation and present a poster. (Formerly CHY 362).
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Lect: 3 hrs./Lab: 3 hrs.
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| Prerequisite: CHY 361 or BCH 361
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Course Weight: 1.00
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Billing Units: 1
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BCH
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501
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Protein Biochem and Proteomics
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In depth examination of protein structure and function, tools for determining biochemical function and structure, analysis of protein-protein interactions, regulatory mechanisms, introduction to high throughput identification and quantification of protein expression; application of proteomics to drug design.
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Lect: 3 hrs.
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| Prerequisites: BCH 261 and BCH 361
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Course Weight: 1.00
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Billing Units: 1
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The course examines mechanisms of signal transduction and intracellular signalling. We will first examine the biochemical tools of signalling pathways including receptor families and their ligands, second messengers, G-Proteins and protein phosphorylation switches. We will then investigate the signalling pathways and networks in biological functions, which may include stress-response, blood pressure control, cell growth, cell migration, and the immune response.
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Lect: 3 hrs.
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| Prerequisite: BLG 311 and (CHY 261 or BCH 261)
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Course Weight: 1.00
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Billing Units: 1
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