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Publications

Peer-Reviewed Journal Publications and Citations

Current Content (listed in Web of Science)

  1. Gennadi Saiko, Timothy Burton, Yasuyuki Kakihana, Kosaku Hatanaka, Ohtonari Takahito, and Alexandre Douplik, "Observation of blood motion in the internal jugular vein by contact & contactless photoplethysmography during physiological testing: case studies", Biomedical Optics Express, January 2024, accepted
  2. Saiko, G., Burton, T., Ramirez-GarciaLuna, J.L., Douplik, A. (2023). Observation of Tissue Oxygenation Changes Using Remote Photoplesysmography with a Smartphone. In: Scholkmann, F., LaManna, J., Wolf, U. (eds) Oxygen Transport to Tissue XLIV. ISOTT 2022. Advances in Experimental Medicine and Biology, vol 1438. Springer, Cham., https://doi.org/10.1007/978-3-031-42003-0_30 (external link, opens in new window) 
  3. Sadrzadeh-Afsharazar F, Douplik A. Non-invasive transcranial alternating current stimulation of spatially resolved phosphenes. Front Neurosci. 2023 Aug 17; 17:1228326
  4. Vashishtha, K.; Xi, F.; Dharmalingam, P.; Douplik, A. Comparative Study of Blue Light with Ultraviolet (UVC) Radiation on Betacoronavirus 1. Appl. Sci. 2023, 13, 1426. https://doi.org/10.3390/app1303142 (external link, opens in new window) 
  5. Cao, M.; Burton, T.; Saiko, G.; Douplik, A. Remote Photoplethysmography with a High-Speed Camera Re-Veals Temporal and Amplitude Differences between Glabrous and Non-Glabrous Skin. Sensors 2023, 23, 615. https://doi.org/10.3390/s23020615 (external link, opens in new window) 
  6. Burton, T., Saiko, G., Cao, M., Douplik, A., Remote photoplethysmography with consumer smartphone reveals temporal differences between glabrous and nonglabrous skin: Pilot in vivo study, J. Biophotonics 2022, 202200187, https://doi.org/10.1002/jbio.202200187 (external link, opens in new window) 
  7. Burton T, Saiko G, Douplik A. Towards Development of Specular Reflection Vascular Imaging. Sensors. 2022; 22(8):2830. https://doi.org/10.3390/s22082830 (external link, opens in new window) 
  8. Saiko, Gennadi et al. "Feasibility of Specular Reflection Imaging for Extraction of Neck Vessel Pressure Waveforms." Frontiers in bioengineering and biotechnology vol. 10 830231. 21 Mar. 2022, doi:10.3389/fbioe.2022.830231 (opens in new window) 
  9. Saiko, G., Dervenis, M., Douplik, A. (2021). On the Feasibility of Pulse Wave Velocity Imaging for Remote Assessment of Physiological Functions. In: Nemoto, E.M., Harrison, E.M., Pias, S.C., Bragin, D.E., Harrison, D.K., LaManna, J.C. (eds) Oxygen Transport to Tissue XLII. Advances in Experimental Medicine and Biology, vol 1269. Springer, Cham. https://doi.org/10.1007/978-3-030-48238-1_62 (external link, opens in new window) 
  10. Saiko G, Zheng X, Betlen A, Douplik A. Fabrication and Optical Characterization of Gelatin-Based Phantoms for Tissue Oximetry. Adv Exp Med Biol. 2020; 1232:369-374. doi: 10.1007/978-3-030-34461-0_47. PMID: 31893433
  11. Pandya, Aditya; Schelkanova, Irina; Douplik, Alexandre, Spatio-angular filter (SAF) imaging device for deep interrogation of scattering media, Biomedical Optics Express 10(9) 4656-4663, 2019,
  12. Pinto, R. N., Hysi, E. , Bagga, K. , Sebastian, J. A., Douplik, A. , Acker, J. P. and Kolios, M. C. (2019), Feasibility of photoacoustic imaging for the non‐invasive quality management of stored blood bags., Vox Sanguinis doi: 10.1111/vox.12828 (external link) 
  13. Pandya, A. H., Kumaradas, J. C., Douplik, A., Miniature optical fiber sensors using surface enhanced Raman spectroscopy (SERS) for remote biochemical sensing. Journal of Biomedical Photonics & Engineering: p. 010301, Feb. 2019. ISSN 2411-2844
  14. Johannes Rebling, Francisco Javier Oyaga Landa, Xosé Luís Deán-Ben, Alexandre Douplik, and Daniel Razansky, Integrated Catheter for Simultaneous Radiofrequency Ablation and Optoacoustic Monitoring of Lesion Progression, Optics Letters, Vol 43(8): 1886-1889, 2018  
  15. Saiko, G., Zheng, X., Betlen, A., Douplik, A., Contrast ratio quantification during visualization of microvasculature, Advances in Experimental Medicine and Biology, Volume 1072: 369-373, 2018
  16. Hohmann, M., Lengenfelder, B., Kanawade, R., Klämpfl, F., Douplik, A., Albrecht, H., Measurement of optical properties of pig esophagus by using a modified spectrometer set-up, Journal of Biophotonics, Volume 11, Issue 1, Article number e201600187, 2018
  17. Saiko, G., Zheng, X., Betlen, A., Douplik, A., Visualization of Methemoglobin Distribution in Tissues: Phantom Validation, Advances in Experimental Medicine and Biology, Volume 1072: 387-390, 2018
  18. O. Wagner, A. Pandya, Y. Chemla, H. Pinhas, I. Schelkanova, A. Shahmoon, Y. Mandel, A. Douplik, Z. Zalevsky, “Non-labelled lens-less micro-endoscopic approach for cellular imaging through highly scattering media”, Bioscience Reports, Volume 38, Issue 1, Article number BSR20170027, 2018
  19. Hohmann, M., Kanawade, R., Klämpfl, F., Douplik, A., Mudter, J., Neurath, M. F. and Albrecht, H. (2016), In-vivo multispectral video endoscopy towards in-vivo hyperspectral video endoscopy. J. Biophoton. Volume 10, Issue 4: 553-564, 2017
  20. Homa Assadi, Valentin Demidov, Raffi Karshafian, Alexandre Douplik, I. Alex Vitkin, "Microvascular contrast enhancement in optical coherence tomography using microbubbles," J. Biomed. Opt. 21(7), 076014 (2016), doi: 10.1117/1.JBO.21.7.076014 (external link, opens in new window) 
  21. G. Saiko, K. Cross, A. Douplik “Mathematical Model of an Innate Immune Response to Cutaneous Wound in the Presence of Local Hypoxia”, Advances in Experimental Medicine and Biology, Oxygen Transport to Tissue XXXVIII, Vol 923: 427-433 (2016)
  22. Schelkanova, Irina and Pandya, Aditya and Saiko, Guennadi and Nacy, Lidia and Babar, Hannan and Shah, Duoaud and Lilge, Lothar and Douplik, Alexandre, „Spatially resolved, diffuse reflectance imaging for subsurface pattern visualization toward development of a lensless imaging platform: phantom experiments “, Journal of Biomedical Optics, V21, Issue 1: 015004- 015012 (2015)
  23. Yossef Danan, Yehonatan Ramon, Jonathan Azougi, Alexandre Douplik, Moshe Sinvani and Zeev Zalevsky, “Decoupling and tuning the light absorption and scattering resonances in metallic composite nanostructures”, Optics Express Vol. 23, Issue 22, pp. 29089-29099 (2015)
  24. Victor Loschenov, Rudolf Steiner, Alexander Potapov and Alexandre Douplik „Novel Photomedicine," International Journal of Photoenergy, Novel Photomedicine Issue Volume 2014, Article ID 498620 (2014)
  25. Homa Assadi, Rafii Karshafian, Alexandre Douplik, “Optical scattering properties of intralipid phantom in presence of encapsulated microbubbles “, International Journal of Photoenergy, Novel Photomedicine Issue Volume 2014, Article ID 471764, 9 pages (2014)
  26. Guennadi Saiko, Alexandre Douplik, “Reflectence of Biological Turbid Tissues Under Wide Area Illumination: Single Backward Scattering Approach “, International Journal of Photoenergy, Novel Photomedicine Issue, Volume 2014, Article ID 241364, 8 pages (2014)
  27. Irina Schelkanova, Aditya Pandya, Guennadi Saiko and Alexandre Douplik, Measurements of diffuse reflectance signal using lensless CMOS imaging chip, Journal of Physics: Conference Series (JPCS), 541, 012098: 1-8 (2014)
  28. Arkady Rudnitsky, Asaf Shahmoon, Alexander Douplik, and Zeev Zalevsky, „Fiber endoscope with inflatable lens “, Optics Communications, vol. 317: 53-56 (2014)
  29. Saiko, G., Pandya, A., Schelkanova, I., Sturmer, M., Beckert, R.J.; Douplik, A., "Optical Detection of a Capillary Grid Spatial Pattern in Epithelium by Spatially Resolved Diffuse Reflectance Probe: Monte Carlo Verification,"Selected Topics in Quantum Electronics, IEEE Journal of, vol.20, no.2, pp.1,9, March-April 2014, doi: 10.1109/JSTQE.2013. 2282278 (2014)
  30. Bay E., Douplik A., Ryazansky D., „Optoacoustic monitoring of cutting efficiency and thermal damage during laser ablation”, Lasers in Medical Science, Volume 29, Issue 3, pp 1029-1035, doi: 10.1007/s10103-013-1434-y (external link) , (2014)
  31. Shahmoon A., Aharon S., Kruchik O., Hohmann M., Slovin H., Douplik A. & Zalevsky Z., “In vivo minimally invasive interstitial multi-functional microendoscopy”, Nature Scientific Reports 3, Article number: 1805, doi:10.1038/srep01805 (2013)
  32. Bay, E., Deán-Ben, X. L., Pang, G. A., Douplik, A. and Razansky, D. (2013), Real-time monitoring of incision profile during laser surgery using shock wave detection. J. Biophoton. doi: 10.1002/jbio.201300151 (2013)
  33. A. Douplik, W. l. Leong, A. Easson, S. Done, B. Wilson, A. Shahmoon, and Z. Zalevsky, Microendoscopic spectral imaging as a tool for small ductual diagnostics: preliminary experience, Journal of Innovative Optical Health Sciences (JIOHS), 05: 1250021 1-7 (2012)
  34. Guennadi Saiko, Alexandre Douplik „Real-Time Optical Monitoring of Capillary Grid Spatial Pattern in Epithelium by Spatially Resolved Diffuse Reflectance Probe “, Innovative Optical Health Sciences (JIOHS), 05, 1250005 1-9 (2012)
  35. Douplik, A., Zanati, S., Saiko, G., Streutker, C., Loshchenov, M., Adler, D., Cho, S., Chen, D., Cirocco, M., Marcon, N., Fengler, J. and Wilson, B. C. (2012), Diffuse reflectance spectroscopy in Barrett’s Esophagus: developing a large field-of-view screening method discriminating dysplasia from metaplasia. J. Biophotonics 7, No. 5, 304–311 doi: 10.1002/jbio.201200114 (2012)
  36. Ekaterina Krauss, Abbas Agaimy, Alexandre Douplik, Heinz Albrecht, Helmut Neumann, Arndt Hartmann, Ralf Hohenstein, Martin Raithel, Markus F. Neurath, Jonas Mudter, Normalized Autofluorescence Imaging Diagnostics in Upper GI Tract: A New Method to Improve Specificity in Neoplasia Detection, International Journal of Clinical and Experimental Pathology, Int J Clin Exp Pathol. 5(9): 956-64. (2012)
  37. O. Sydoruk; O. Zhernovaya; V. Tuchin; A. Douplik, Refractive index of solutions of human hemoglobin from the near-infrared to the ultraviolet range: Kramers-Kronig analysis J. Biomed. Opt. 17 (11), 115002 (2012)
  38. A. Korovin, A. Douplik, Prospective for creating a near-field scalpel for laser surgery, Optics Letters, Vol. 37 Issue 21, pp.4510-4512 (2012)
  39. Florian Stelzle, Werner Adler, Azhar Zam, Katja Tangermann-Gerk, Christian Knipfer, Alexandre Douplik, Michael Schmidt and Emeka Nkenke, In Vivo Optical Tissue Differentiation by Diffuse Reflectance Spectroscopy: Preliminary Results for Tissue-Specific Laser Surgery SURG INNOV, vol. 19 no. 4, 385-393 (2012)
  40. Florian Stelzle, Azhar Zam, Werner Adler, Katja Tangermann-Gerk, Alexandre Douplik, Emeka Nkenke and Michael Schmidt “Optical Nerve Detection by Diffuse Reflectance Spectroscopy for Feedback Controlled Oral and Maxillofacial Laser Surgery”, Journal of Translational Medicine, 09:20 (2011)
  41. Zhernovaya O., Sidoruk O., Tuchin V., Douplik A., “The refractive index of human hemoglobin in the visible range”, Phys Med Biol. 56(13): 4013-21 (2011)
  42. Stelzle F., Tangermann-Gerk K., Adler W., Zam A., Schmidt M., Douplik A., Nkenke E., "Diffuse Reflectance Spectroscopy for Optical Soft Tissue Differentiation as Remote Feedback Control for Tissue-Specific Laser Surgery", Lasers in Surgery & Medicine, 42(4): 319-325 (2010)
  43. Douplik A., Chen D., Akens M., Cirocco M., Bassett N., Marcon N., Fengler J. and Wilson B., "Assessment of Photobleaching During Endoscopic Autofluorescence Imaging of the Lower GI Tract," Lasers in Surgery and Medicine, Volume 42(3): 224-231 (2010)
  44. Douplik A., Zam A., Hohenstein R., Kalitzeos A., Nkenke E., Stelzle F., "Limitations of Cancer Margin Delineation by Means of Autofluorescence Imaging under Conditions of Laser Surgery," Journal of Innovative Optical Health Sciences (JIOHS), Volume: 3, Issue: 1: 45-51, (2010)
  45. Douplik A., Leong W. L., Easson A. M., Done S., Netchev G., Wilson B. C., “A Feasibility Study of Autofluorescence Mammary Ductoscopy,” Journal of Biomedical Optics 14 (4), 044036 1-6, (2009)
  46. Lai B., Loshchenov M., Douplik A., Rusnov R., Jimenez-Davila M., Netchev G., Lilge L., “Three-Dimensional Fluence Rate Measurement and Data Acquisition System for Minimally Invasive Light Therapies,” Review of Scientific Instruments 80 (4), 43104.1-5, (2009)
  47. Rioux D., Laferrière M., Douplik A., Shah D., Lilge L., Kabashin A. V., Meunier M., “Silicon Nanoparticles Produced by Femtosecond Laser Ablation in Water as Novel Contamination-Free Photosensitizers,” Journal of Biomedical Optics 14 (2): 021010.1-5, (2009)
  48. Douplik A., Morofke D., Chiu S., Bouchelev V., Mao L., Yang V., Vitkin A., “In Vivo Real Time Monitoring of Vasoconstriction and Vasodilation by a Combined Diffuse Reflectance Spectroscopy and Doppler Optical Coherence Tomography Approach,” Lasers in Surgery and Medicine 40 (5), 323-331, (2008)
  49. Zanati S.A., Marcon N.E., Cirocco M., Basset N., Streutker C., Kandel G.P., Kortan P.P., Rychel S., Douplik A., Wilson B., “Onco-LIFE Fluorescence Imaging during Colonoscopy Assists in the Differentiation of Adenomatous and Hyperplastic Polyps and Improves the Detection Rate of Dysplastic Lesions in the Colon,” Gastroenterology 128, A27-8, (2006)
  50. Lilge L., Pomerleau-Dalcourt N., Douplik A., Selman S.H., Keck R.W., Szkudlarek M., Pestka M., Jankun J., “Transperineal in Vivo Fluence-Rate Dosimetry in the Canine Prostate During SnET2-Mediated PDT,” Physics in Medicine and Biology 49 (14), 3209-3225, (2004)
  51. Jankun J., Lilge L., Douplik A., Keck R., Pestka M., Sykudlarek M., Stevens P.J., Lee R.J., Selman S.H., “Optical Characteristics of the Canine Prostate at 665 NM Sensitized with Tin Etiopurpurin Dichloride: Need for Real-Time Monitoring of Photodynamic Therapy,” Journal of Urology 172 (2), 739-743, (2004)
  52. Stratonnikov A., Douplik A., Loschenov V., “Oxygen Consumption and Photobleaching in Whole Blood Incubated with Photosensitizer Induced by Laser Irradiation,” Laser Physics 13 (1), 1-21, (2003)
  53. Douplik A.Y., Stratonnikov A.A., Loschenov V.B., Lebedeva V.S., Derkacheva V.M., Vitkin A., Rumyanceva V.D., Kusmin S.G., Mironov A.F., Luk’yanets E.A. “Study of Photodynamic Reactions in Human Blood,” J. of Biomed. Optics 5 (3), 338-349, (2000)
  54. Stratonnikov A.A., Douplik A.Y., Loschenov V.B., “Oxygen Consumption and Its Transport in Tissues During Photodynamic Therapy of Tumors,” Oxygen transport to tissues XXI, Ed. A. Eke and D.T. Delpy, Kluwer Academic/Plenum Publishers, NY, 515-524, (1999)
  55. Stratonnikov A., Douplik A., Loschenov V. “Oxygen Consumption and its Transport in Tissues during Photodynamic Therapy of Tumors and Whole Blood”, Advances in Experimental Medicine and Biology 471, p. 515-523, (1999)

    Other peer-reviewed publications (non-Current Content peer-reviewed journals)
  56.  DeVos, L.; Saiko, G. and Douplik, A. (2023). Skin Tone via Device-Independent Colour Space. In Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies - BIOIMAGING, ISBN 978-989-758-631-6; ISSN 2184-4305, SciTePress, pages 124-128. DOI:10.5220/0011748100003414
  57.  Burton, T.; Saiko, G. and Douplik, A. (2022). Remote PPG Imaging by a Consumer-grade Camera under Rest and Elevation-invoked Physiological Stress Reveals Mayer Waves and Venous Outflow. In Proceedings of the 15th International Joint Conference on Biomedical Engineering Systems and Technologies - BIOIMAGING, ISBN 978-989-758-552-4; ISSN 2184-4305, SciTePress, pages 153-159.
  58. Davidenko N., Zheng X., Davidenko I., Pavlov V., Chuprina N., Kuranda N., Studzinsky S., Pandya A., Mahdi H., Ladak A., Gergely C., Cuisinier F., Douplik A, “Holographic interferometry real time imaging of refraction index 2D distribution and surface deformations in biomedicine”, In Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies - BIOIMAGING: BIOIMAGING, 5 pages (accepted in January 2021)
  59. Saiko, G. and Douplik, A. (2021). Contrast Ratio during Visualization of Subsurface Optical Inhomogeneities in Turbid Tissues: Perturbation Analysis. In Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies - BIOIMAGING: BIOIMAGING, 10 pages (accepted in January 2021)
  60. F. Sadrzadeh-Afsharazar, S. Mann and A. Douplik, “Phosphenotype”, An extended social-distancing sensory modality for the blind," IEEE 2020 Fourth International Conference on Multimedia Computing, Networking and Applications (MCNA), VALENCIA, Spain, 2020, pp. 147-152, doi: 10.1109/MCNA50957.2020.9264302.
  61. A. Easson, A. Pandya, J. Pasternak, N. Mohammed and A. Douplik, "Improving the patient cancer experience: Multispectral (White Light/Autofluorescence/Raman) Needle Endoscopy for cancer diagnostics in breast and thyroid," SPIE-OSA 2020 Photonics North (PN), Niagara Falls, ON, Canada, 2020, pp. 1-2, doi: 10.1109/PN50013.2020.9166986.
  62. Saiko, G. and Douplik, A. (2020). Extraction of Intrinsic Fluorescence in Fluorescence Imaging of Turbid Tissues. In Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 2 BIOIMAGING: BIOIMAGING, ISBN 978-989-758-398-8, ISSN 2184-4305, pages 123-129. DOI: 10.5220/0008919401230129
  63. Saiko, G. and Douplik, A. (2020). Water-sensitive Gelatin Phantoms for Skin Water Content Imaging. In Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 2 BIOIMAGING: BIOIMAGING, ISBN 978-989-758-398-8, ISSN 2184-4305, pages 130-134. DOI: 10.5220/0008919501300134
  64. A. Shahmoon, A. Douplik, Z. Zalevsky “Micro-size multi-core fiber as an imaging tool for internal organ examination”, Physics Procedia 39 (2012) 830 – 834
  65. Alexandre Douplik, Wey L. Leong, Alexandra Easson, Susan J. Done, George Netchev and Brian C. Wilson “Preliminary experience of autofluorescence mammary ductoscopy “, Biomedical Optics and Medical Imaging SPIE newsroom, 24 October 2011
  66.  Alexandre Douplik, David Rioux, Marie Laferrière, Olga Zhernovaya, Lothar Lilge, Duoaud Shah, Michel M. Meunier, Andrei V. Kabashin “Photodynamic Therapy with Silicon Nanoparticles “, Photodiagnosis and Photodynamic Therapy, V. 8 (2): 207 (2011)
  67. R. Kanawade, G. Saiko, and A. Douplik, Best Dynamic Wavelength Range for Shock Detection via Blood Vessel Density Pattern, Physics Procedia 5: 659–664 (2010)
  68. Stelzle F., Zam A., Werner A., Douplik A., Tangermann-Gerk K., Nkenke, E., Neukam, F., Schmidt M., "Diffuse reflectance spectroscopy for optical nerve identification: Preliminary ex vivo results for feedback controlled oral and maxillofacial laser surgery." Physics Procedia 5: 647-654 (2010)
  69. Douplik, A., "Combined surgery and photodynamic therapy of cancer." Physics Procedia 5: 641-645, (2010)
  70. Zam A., Stelzle F., Tangermann-Gerk K., Werner A., Nkenke, E., Neukam, F., Schmidt M., Douplik A., "In vivo soft tissue differentiation by diffuse reflectance spectroscopy: preliminary results." Physics Procedia 5: 655-658 (2010)
  71. Douplik A., “Photodynamic Therapy with nanoparticles.” Photodiagnosis and Photodynamic Therapy, V. 7, Suppl 1: 35 (2010)
  72.  Vetshev P.S., Chilingaridi K.E., Ippolotov L.I., Kcharnas S.S., Loschenov V.B., Gabaidze D.I., Douplik A.Y., “The First Experience of the Laser Spectroscopy Application in Surgical Treatment of Thyroid Gland Diseases,” Problems of Endocrinology 1, 17 – 20, (1999)
  73. Stratonnikov A., Loschenov V., Douplik A., Konov V. “The Control of Blood Oxygenation during Photodynamic Therapy in Biological Tissues and Blood”, Journal of Russian Chemistry, V. XLII, N5, p. 63-67, (1998) (in Russian)
  74.  Douplik A., Loschenov V. B., Stratonnikov A. A., “Blood Oxygenation and Hemolysis Monitoring by Fiber Optic Spectrometer During Photodynamic Procedure in Vitro,” Medical & Biological Engineering & Computing 35, Suppl. P. I, B69-OS2.04, (1997)

Intellectual Property

Invention Disclosure

  1. Remote pulse wave velocity monitoring device, Guennadiy Saiko, Alexandre Douplik, Ryerson Invention Disclosure, 2018, 2019, 2020

Patents

  1. Schelkanova I, Pandya A, Zalevsky Zeev, Douplik Alexandre, Spatial Phase Filter And Illumination Device; US US 11,675,177 B2, June 13, 2023
  2. Schelkanova I, Pandya A, Zalevsky Zeev, Douplik Alexandre, Spatial Phase Filter And Illumination Device; US 17/259,494, January 11, 2021
  3. Ultrafine Needle Endoscope Apparatus for Deep Interstitial Examination by White Light Imaging, Autofluorescence Imaging and Raman Spectroscopy, Alexandra Easson, Alexandre Douplik, PCT application: PCT/CA2020/000135, 2020
  4. Schelkanova I, Pandya A, Zalevsky Zeev, Douplik Alexandre, Spatial Phase Filter And Illumination Device; Patent Application Canada # 3,105,130; filing priority July 10, 2019; the Canadian National Phase Entry Dec 24, 2020
  5. Faraz Sadrzadeh-Afsharazar, Alexandre Douplik, Novel Device for Direct Non-Invasive Modulated Stimulation of Optical Nerve, PCT/CA2021/050557, April 23, 2021
  6. A. Douplik and G. Sayko; Method, Apparatus and System for Robust Measurement of Blood Perfusion and Pulse Wave Imaging, US Prov. Patent App. No. 63/150264, February 17, 2021
  7. Novel Device for Direct Non-Invasive Modulated Stimulation of Optical Nerve, Faraz Sadrzadeh-Afsharazar, Alexandre Douplik, US Prov. Patent App. No. 63/014,616, 2020
  8. Spatial phase filter and illumination device for deep interrogation of strongly scattering media and uses thereof Schelkanova Irina, Pandya Aditya, Zalevsky Zeev, Douplik Alexandre PCT application: PCT/CA2019/050951, filed: July 10, 2019
  9. Development of Ultra-Fine Needle Endoscope for Deep Interstitial Examination by Conventional, Autofluorescence Imaging and Raman Spectroscopy, A. Easson, A.Douplik, US Prov. Patent App. No. 62/946,955, Dec 2019
  10. A Spatial Phase gated and pixel cross talk gated imaging and illumination device for deep interrogation of strongly scattering media,” Schelkanova I, Pandya A, Zalevsky Zeev, Douplik Alexandre, US patent 62696519, July 11, 2018
  11. Apparatus and method for remote assessment of surface tissue physiology, G.Saiko, K. Cross, A. Douplik, US patent Serial No: US 62304555, 2016
  12. Method for Identifying benign and malignant lesions in Barrett’s esophagus using white light endoscopy, A. Douplik, D. Adler, B. Wilson, N. Marcon, US patent US9295392, 2016
  13. Method for Identifying benign and malignant lesions in Barrett’s esophagus using white light endoscopy, A. Douplik, D. Adler, B. Wilson, N. Marcon, US patent Serial No: US 20130178748, 2013
  14. A. Douplik, D. Adler, B. Wilson, N. Marcon “Method for Identifying malignancies in Barrett’s esophagus using white light endoscopy”, US patent Serial No:20100087741, 2010.
  15. V. Loschenov, A. Douplik, G. Vorozhtsov, Y. Ablitzov, E. Luk’yanetz “Method for suppressing cancer tumor growth”, Patent of Russian Federation Publication #2159644; (FIPS), Publication date 2000/11/27
  16. V. Loschenov, A. Douplik, Vorozhtsov G.N., Y. Ablitzov, E. Luk’yanetz “Method for suppressing cancer tumor growth”, Patent of Russian Federation Publication #98113166; (FIPS), Publication date 2000/04/10.
  17. V. Loschenov, A. Douplik, D. Klimov, K. Linkov “Method to prevent and cure diseases of the periodontium and mucous membrane of mouth”, Patent of Russian Federation Publication #97106366; (FIPS), Publication date 1999/04/20.

Non-Peer-Reviewed Publications

Oral Presentations with Accompanying Conference Papers

1.     Wagner, O., Pandya, A., Chemla, Y., Pinhas, H., Schelkanova, I., Shahmoon, A., Mandel, Y., Douplik, A., Zalevsky, Z., Lens-less Micro-endoscopy through highly scattering media, IEEE-Proceeding, Conference on Lasers and Electro-Optics, (CLEO) 2018

2.     Pandya A., Kumaradas, C., Douplik, A., Raman spectroscopy and biochemical modeling of ex-vivo breast tissues and deparaffinized tissue samples, Optics InfoBase Conference Papers, Volume Part F110-Sensors Zurich; Switzerland, Code 140148, 2018

3.     Pandya, A., Karia, H., Tajouri, S.,Zheng, X.,Gergely, C.,Kolios, M.,Douplik, A., Tissue phantoms with patterned oxygenation for photoacoustic applications, Optics InfoBase Conference Papers, Volume Part F98- Bragg Gratings, Photosensitivity and Poling in Glass Waveguides and Materials, Zurich; Switzerland, Code 140028, 2018

4.     N. Davidenko, H. Mahdi, X. Zheng, I. Davidenko, V. Pavlov, N. Kuranda, N. Chuprina, S. Studzinsky, A. Pandya (external link) , H. Karia, S. Tajouri, M. Dervenis (external link) , C. Gergely, A. Douplik (external link) , "Holographic interferometry imaging monitoring of photodynamic (PDT) reactions in gelatin biophantom", Proc. SPIE 10612, Thirteenth International Conference on Correlation Optics, 106120H; http://dx.doi.org/10.1117/12.2305576 (external link) , 2018

5.     N. Davidenko, X. Zheng, I. Davidenko, V. Pavlov, N. Chuprina, S. Studzinsky, A. Pandya, H. Karia, S. Tajouri, M. Dervenis, and A. Douplik, "Holographic Interferometry Monitoring of Hyperthermal and Photochemical Reactions with Human Hemoglobin," in Digital Holography and Three-Dimensional Imaging, OSA Technical Digest (online) (Optical Society of America), paper Th4A.2, 2017

6.     Ruben N. Pinto, Karan Bagga, Alexandre Douplik, Jason P. Acker, Michael C. Kolios, "Photoacoustic measurements of red blood cell oxygen saturation in blood bags in situ", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 1006440; doi: 10.1117/12.2253530, 2017

7.     Yossef Danan; Tali Ilovitsh; Danping Liu; Hadar Pinhas; Moshe Sinvani; Yehonatan Ramon; Jonathan Azougi; Alexandre Douplik; Zeev Zalevsky Plasma dispersion effect assisted nanoscopy based on tuning of absorption and scattering resonances of nanoparticles, Proc. SPIE. 9721, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII, 97210J., doi: 10.1117/12.2210800, 2016

8.     H. Assadi, A. Pandya, I. Schelkanova, R. Karshafian, and A. Douplik, “Blood flow contrast enhancement for diffuse reflectance imaging by microbubbles: A phantom study," SPIE Proceeding, Volume 9715, Article number 97151F, 2016

9.     H. Assadi, A. Pandya, I. Schelkanova, R. Karshafian, and A. Douplik, “Contrast enhancement for diffuse reflectance imaging by microbubbles," in Biomedical Optics, OSA Technical Digest (online) (Optical Society of America), paper OW4D.4, 2016

10.  Pandya, Aditya; Hilaneh, Jawad; Kumaradas, Carl; Douplik, Alexandre „Identifying/digital staining of diseased regions by monitoring disease specific marker molecules using Raman spectral libraries “, OSA Technical Digest (CD) (Optical Society of America), Optical Molecular Probes, Imaging and Drug Delivery, paper OW3D.5, doi: 10.1364/OMP.2015.OW3D.5 (external link) , 2015

11.  Erwin Bay; Xosé Luis Dean Ben; Genny A. Pang; Alexandre Douplik; Daniel Razansky, Three-dimensional tracking of lesion profile during laser surgery based on shock wave detection, Proc. SPIE. 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89431N. (March 03, 2014) doi: 10.1117/12.2040376, 2014

12.  Douplik, Alexandre; Schelkanova, Irina; Pandya, Aditya; Lilge, Lothar; Macdonald, Graham; Shah, Duoaud „MICROVASCULAR PATTERNS MONITORING VIA LENSLESS CMOS CHIP (external link) “, OSA Technical Digest (online) (Optical Society of America),  paper BS3A.48, doi: 10.1364/BIOMED.2014.BS3A.48 (external link) , 2014

13.  Bay E, Douplik A, Razansky D, Optoacoustic monitoring of cutting and heating processes during laser ablation Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 8581; 85813X (2013), doi:10.1117/12.2005027

14.  Martin Hohmann, Alexandre Douplik, Janani Varadhachari, Aulia Nasution, Jonas Mudter, Markus Neurath, and Michael Schmidt “Preliminary results for hyperspectral videoendoscopy diagnostics on the phantoms of normal and abnormal tissues: towards gastrointestinal diagnostics”, Proc. SPIE 8087, 80872N (2011)

15.  Jan Paulus, Joachim Hornegger, Michael Schmidt, Alexandre Douplik, Georg Michelson “A Polarized Dual-Projection System to Evaluate Stereo Vision”, Proc. of ARVO (The Association for Research in Vision and Ophthalmology, Inc.) Conference, 2011

16.  Krauss E., Douplik A., Albrecht H., Agaimy A., Hohenstein R., Neurath M., Mudter J. “Normalized autoflluorescence imaging diagnostics in upper GI tract: a new method to improve specificity in neoplasia detection”, Gastroenterologie Viszeralchirurgie,  Viszeralmedizin, 5. Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie gemeinsam mit den Arbeitsgemeinschaften der DGAV P070: 228 (2011)

17.  Zam A., Stelzle F., Tangermann-Gerk K., Adler W., Nkenke E., Schmidt M., Douplik A., Tissue differentiation by diffuse reflectance spectroscopy for automated oral and maxillofacial laser surgery: ex vivo pilot study, Proc. SPIE V7555, p. 16-1:6, 2010.

18.  A. Zam, F. Stelzle, E. Nkenke, K. Tangermann-Gerk, M. Schmidt, W. Adler, and A. Douplik Tissue-Specific Laser Surgery: Hard Tissue Differentiation by Diffuse Reflectance Spectroscopy ex vivo, in Frontiers in Optics, OSA Technical Digest (CD) (Optical Society of America, 2009), paper FThP2, 2009

19.  A. Kalitzeos, A. Zam, F. Stelzle, E. G. Hahn, M. Raithel, and A. Douplik, Enhancement of Cancerous/Normal Tissue Contrast via Combined White Light and Fluorescence Image Processing: Initial Investigation ex vivo, in Novel Optical Instrumentation for Biomedical Applications IV, C. Depeursinge and I. Vitkin, eds., Vol. 7371 of Proceedings of SPIE-OSA Biomedical Optics (Optical Society of America, 2009), paper 7371_0N, 2009

20.  A. Douplik, D. Morofke, S. Chiu, V. Bouchelev, L. Mao, V. Yang, and A. Vitkin, In vivo Real Time Combined Diffuse Reflectance-OCT Monitoring of Vasoconstriction and Vasodilation, Biomedical Optics, OSA Technical Digest (CD) (Optical Society of America, 2008), paper BTuE8, 2008.

21.  A. Douplik, S. Zanati, N. Marcon, M. Cirocco, B. Wilson, J. Boehm, S. Rychel, and J. Fengler, Combined autofluorescence and white-light endoscopy for improved detection of dysplastic colonic lesions, in Biomedical Optics, Technical Digest (CD) (Optical Society of America, 2008), paper ME63, 2006. 

22.  Alexandre Douplik, David Shalaby, Brian C. Wilson, Joseph Perry A method to improve the reproducibility of in vivo reflectance spectroscopy, Proc. SPIE V5695, p. 335-339, 2007

23.  Alexandre Douplik, David Shalaby, Brian Wilson, The spectral dependence of fiberoptic probe pressure on tissue during in vivo diffuse reflectance spectroscopy, in Biomedical Optics 2004 Technical Digest (Optical Society of America, Washington, DC, 2004), FG04, 2007

24.  Netchev G., Pomerleau N., Douplik A., Lilge L., Integrating Cylinder for Calibration   of Cylindrical Diffusers and Fluence and PO2 Sensors, SPIE VTD01, p.235-6, 2002.

25.  A.Y. Douplik, V. Loschenov, D. Klimov, K. Linkov New method of fluorescence diagnostics, photodynamic preventive maintenance, and treatment of diseases of the periodontium and mucous membrane of mouth, SPIE 3196, p. 206-209, 1998

26.  Alexandre Y. Douplik, Victor B. Loschenov, Victoria S. Lebedeva, Valentina M. Derkacheva, V. D. Rumyanceva, L. V. Chasovnikova, S. G. Kusmin, Andrei F. Mironov, Eugeny A. Lukyanets, V. I. Sergienko Oxygen consumption during photodynamic reactions in human blood, Proc. SPIE V. 3254, p. 461-468, 1998

27.  Alexander A. Stratonnikov, Alexandre Y. Douplik, D. V. Klimov, Victor B. Loschenov, S. V. Mizin, Influence of light irradiation on blood oxygen saturation level in vitro and in vivo during photodynamic therapy, Proc. SPIE V. 3247, p. 128-136, 1998

28.  Douplik, M. Kessler, Y. Kakihana, A. Krug, Noninvasive investigation of skin local hypothermia influence upon local oxygenation and hemoglobin concentration, SPIE 2979, p. 375-377, 1997

29.  Yasuyuki Kakihana, Manfred D. Kessler, Alexandre Y. Douplik, Alfons Krug, Stable and reliable measurement of intracapillary hemoglobin-oxygenation in human skin by EMPHO II, SPIE 2979, p. 378-389, 1997

30.  A. Douplik, V. B. Loschenov, Voroztsov G., Kogan E., Kusin M., Ablitsov Y., Illyina O, Phenomenon of PDT-induced post-irradiation apoptosis in biological liquids and cancer cells using sulphonated phtalocyanine aluminum photosensitizer, SPIE 3191, p. 124-129, 1997

31.  Alexander A. Stratonnikov, Alexandre Y. Douplik, D. V. Klimov, Victor B. Loschenov, Gennadii A. Meerovich, S. V. Mizin, Galina I. Fomina, Natalia I. Kazachkina, Raisa I. Yakubovskaya, Yu. V. Budenok, Absorption spectroscopy as a tool to control blood oxygen saturation during photodynamic therapy, SPIE 3191, p. 58-66, 1997

32.  Alexandre Y. Douplik, Victor B. Loschenov and Alexander A. Stratonnikov, Spectra changes of whole blood with sulphonated aluminum phtalocyanine photosensitizer during photodynamic therapy in vitro, Proc. SPIE 2923, 44, 1996

33.  Douplik Alexandre, Loschenov Victor B., Identification of optical parameters of the whole blood depending on its oxygenation level, SPIE-Proc., Vol.2678, USA, 1996.

34.  Alexandre Y. Douplik, Victor B. Loschenov, Vladislav G. Malinin, S. Proscurnev and D. V. Klimov, Changes of optical parameters of moving whole blood depending on shear rate, Proc. SPIE 2923, 35, 1996

35.  Douplik Alexandre, Loschenov V.B, Identification of spectroscopic and optical parameters of whole blood depending on its concentration and layer thickness, SPIE-Proc., Vol. 2624, USA, p. 165-176, 1995

36.  Alexandre Y. Douplik and Anna M. Posypanova, Investigation of phtalocyanine Al photosensitizer and blood interaction, Nadezgda L. Torshina, Victor B. Loschenov, Alexander A. Stratonnikov, Proc. SPIE 2325, 389, 1995

37.  Douplik A.Y Use of the concept of “Specific Power Density of blood” for for parametrization of low-level laser irradiation”., SPIE-Proceeding Vol. 1981, p. 240-244, 1993

38.  Alexandre Y. Douplik, Y. N. Gordeev and Ilya V. Yaroslavsky Calculation of specific power density of blood for intravenous low-level laser therapy, Proc. SPIE 1981, 240 (1993)

Poster Presentations with Accompanying Conference Papers

39.  Schelkanova; A. Pandya; G. Saiko; L. Nacy; H. Babar; D. Shah; L. Lilge; A. Douplik, Evaluation of spatially resolved diffuse reflectance imaging for subsurface pattern visualization towards applicability for fiber optic lensless imaging setup: phantom experiments and simulation, Proc. SPIE. 9537, Clinical and Biomedical Spectroscopy and Imaging IV, 95371T. (July 15, 2015) doi: 10.1117/12.2183828

40.  Homa Assadi; Vincent Lee; Raffi Karshafian; Alexandre Douplik, Study optical properties of biological tissue in the presence of microbubbles, Proc. SPIE. 9321, Optical Interactions with Tissue and Cells XXVI, 93210X. (March 05, 2015) doi: 10.1117/12.2075673

41.  Rajesh Kanawade, Gennadi Sayko, Michael Schmidt, and Alexandre Douplik “In vivo monitoring of vessel density pattern in skin phantoms for the application of early sign of shock detection by using diffuse reflectance spectroscopy”, Proc. SPIE 7890, 789009 (2011)

42.  Rajesh Kanawade, Gennadiy Saiko, Alexandre Douplik “Monitoring of the vessel capillary density spatial pattern in epithelium phantom model”, Proc. SPIE 7715, 771526 (2010)

43.  R. Kanawade, G. Saiko, and A. Douplik Monitoring of Epithelial Capillary Density, in Novel Optical Instrumentation for Biomedical Applications IV, C. Depeursinge and I. Vitkin, eds., Vol. 7371 of Proceedings of SPIE-OSA Biomedical Optics (Optical Society of America, 2009), paper 7371_1L, 2009

44.  A. Zam, F. Stelzle, E. Nkenke, K. Tangermann-Gerk, M. Schmidt, W. Adler, and A. Douplik Soft tissue differentiation by diffuse reflectance spectroscopy, in Clinical and Biomedical Spectroscopy, I. Georgakoudi, J. Popp, and K. Svanberg, eds., Vol. 7368 of Proceedings of SPIE-OSA Biomedical Optics (Optical Society of America, 2009), paper 7368_21, 2009

Presentations (Oral Presentations with Published Abstracts)

45.  Douplik A, Hyperspectral and fluorescence biomedical imaging, The international Congress of Imaging Science (ICIS), Tel-Aviv (Israel) (2014)

46.  A. Douplik, “New generation of advanced microendoscopes”, Proceedings of Topical Problems of Biophotonics, Nizhny Novgorod, Russia, 21-27 July, 2013

47.  A. Douplik, „Microendoscopy of small ducts as a potential tool for guiding and monitoring intruductual biopsy and therapy “, Proceedings of Canadian Assosiation of Physicists Congress, Physics in Canada, V. 67-2 (Supplement), W2-13, 2012.

48.  A. Douplik, M. Hohmann, W. L. Leong, A. M. Easson, S. Done, H-G. Schaaf, B. C. Wilson, “Fluorescence microendoscopy of small ducts as a potential tool for guiding and monitoring laser intruductual surgery”, Proceedings of Conference of Laser Surgery and Medicine 2012 (CLSM 2012), April 26-27, 2012, Yokohama, Japan, pp. 40-41 (2012)

49.  A. Shahmoon, A. Douplik, Z. Zalevsky, “Multicore-fiber microendoscope as a potential tool for intravascular laser surgery guidance”, Proceedings of Conference of Laser Surgery and Medicine 2012 (CLSM 2012), April 26-27, 2012, Yokohama, Japan, pp. 60-61 (2012).

50.  E. Bay, A. Douplik, and D. Razansky “Remote optoacoustic feedback for laser surgery”, Proceedings of Conference of Laser Surgery and Medicine 2012 (CLSM 2012), April 26-27, 2012, Yokohama, Japan, pp. 56-57 (2012).

51.  O. Zhernovaya, V. Tuchin, A Douplik, “Multi-Wavelength Monitoring of the Real Part of Hemoglobin Refraction Index During Heating”, Proceedings of Conference of Laser Surgery and Medicine 2012 (CLSM 2012), April 26-27, 2012, Yokohama, Japan, pp. 58-59 (2012).

52.  A. Douplik, W. L. Leong, A. M. Easson, S. Done, G. Netchev, B. C. Wilson, “Preliminary experience of autofluorescence mammary ductoscopy”, Proceedings of Topical Problems of Biophotonics, July 2011, St. Petersbourg-Nizhny Novgorod, Russia, 15-22 July, 2011

53.  Douplik A. Optical feedback and real time monitoring for laser surgery, Proc. Of International Symposium on Laser Medical Applications, Moscow, Russia, 5-6 of July 2010, p. 106.

54.  Eisa F., Januts J., Pöschinger T., Perez A., Langenbucher A., Douplik A, Studies on the optical properties and reproducibility of agar- and resinstabilized tissue-like phantoms, Douplik A., 18th INTERNATIONAL LASER PHYSICS WORKSHOP Proceeding, Barcelona, 2009.

55.  Douplik A., Gordeev Y., Yaroslavsky I., Calculation of the mean irradiation of blood for the intra-venous laser therapy, Abstracts of Contemporary status of the problem of laser technology application in clinical practice conference Proceeding, Russian State Medical University, Moscow, Russia (in Russian), p. 87-89, 1992.

Book Chapters

56. Robert Bartlett, G. Saiko and A. Douplik "Optical Methods in Diabetic Foot Ulcer (DFU) Screening", Chapter 2 in "Biomedical Photonics for Diabetes Research" CRC Press, Ed. V. Tuchin and A. Dunaev, 2022

57. Douplik, A. Stratonnikov, O. Zhernovaya and V. Loschenov “Modifications of Blood Optical Properties during Photodynamic Reactions in Vitro and in Vivo”, Chapter 20 in “Advanced optical cytometry: methods and disease diagnoses”, Edited by V.V. Tuchin, Wiley-VCH, 2011

58. A. Douplik “Intraoperative OCT”, Chapter 25 in Handbook of Biophotonics, Edited by J. Popp, V. Tuchin, M. Strehle Wiley-VCH, 2011

59.  A. Douplik “OCT in urology”, Chapter 31 in Handbook of Biophotonics, Edited by J. Popp, V. Tuchin, M.Strehle Wiley-VCH, 2010, April 2011

60.  A. Douplik, G. Saiko, I. Schelkanova, V. V. Tuchin „The response of tissue to laser light “, Chapter 2 in Lasers for medical applications, Edited by H. Jelinkova, Woodhead Publishing, 2012

61.  Alexandre Douplik “Laser Surgery”, Chapter 01011 in Comprehensive Biomedical Physics, edited by Anders Brahme (ELS), Elsevier, 2014

62.  I. Schelkanova, A. Pandya, A. Muhaseen, G. Saiko and A. Douplik „Early optical diagnosis of pressure ulcers “, Chapter 21 in Biophotonics for medical application, Ed. I. Meglinsky, Elsevier, 2015