Fluorescence Activation and Enhancement with Photogenerated Radicals, Pre-fluorescent Probes and Silver Nanostructures
- Date
- September 10, 2021
- Time
- 12:00 PM EDT - 2:00 PM EDT
- Location
- Virtual Zoom
- Open To
- Event open to Students, Faculty, Staff, Post-Doctoral Fellows, Public
- Contact
- Sarah Kovacs skovacs@torontomu.ca
Candidate: Karol Golian
Supervisor: Dr. Stefania Impellizerri
Abstract:
This thesis proposes a boron-dipyrromethene (BODIPY) fluorophore-based radical sensing
system covalently linked to 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO), a paramagnetic
nitroxide, known to quench fluorescence non-radiatively through electron exchange. Introduction of a free radical creates a diamagnetic product, resulting in the restoration of fluorescence due to the inhibition of its quenching pathway. This has been successfully applied to the activation of a pre-fluorescent system with the addition of metal enhanced fluorescence via silver nanoparticles. Further research looks at extending the π conjugation of the BODIPY based pre-fluorescent probe to bathochromically shift its spectroscopic properties to enhance its potential in biological monitoring applications.
